2015年，李雪在华中科技大学武汉光电国家研究中心读硕士，她形容当时的研究“就像拆解电脑”，虽然每天与脑组织切片打交道，可即便把“电脑”拆开，看到了里面的每一个部件，仍然无法清楚地知道每项功能是如何实现的。更何况，人脑的复杂与精密程度数万倍于电脑。
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Over time, it evolved into a universal reaction image, a shorthand for anyone who had missed the moment entirely. You didn't need to know Slowpoke's Pokédex stats to understand it. You just needed to know what it felt like to realize something after everyone else already had.